Author

T. H. Stracker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. Terre· 2 shared H. Lu· 2 shared H. Zhao· 2 shared I. Garcia-Cao· 2 shared J. Querol· 2 shared J. Wang· 2 shared M. Lewis· 2 shared S. Roy· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

B. Terre

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

M. Lewis, B. Terre, P. A. Knobel, T. Cheng, H. Lu, C. S. Attolini, J. Smak, E. Coyaud, I. Garcia-Cao, J. Querol, G. Gil-Gomez, G. Piergiovanni, V. Costanzo, S. Peiro, B. Raught, , T. H. Stracker

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

bioRxiv · Dec 2, 2022 · PreprintCell Biology

Rational optimization of a transcription factor activation domain inhibitor

S. Basu, P. Martinez-Cristobal, M. Pesarrodona, M. Frigole-Vivas, E. Szulc, M. Lewis, A. Banuelos, C. Sanchez-Zarzalejo, S. Bielskute, J. Zhu, K. Pombo-Garcia, C. Garcia-Cabau, C. Batlle, B. Mateos, M. Biesaga, , X. Salvatella

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

bioRxiv · Aug 18, 2022Biochemistry

Loss of HMCES is synthetic lethal with APOBEC activity in cancer cells

J. Biayna, I. Garcia-Cao, M. M. Alvarez, M. Salvadores, J. Espinosa-Carrasco, M. McCullough, F. Supek, T. H. Stracker

The paper identifies HMCES as a synthetic lethal partner of APOBEC3A in cancer cells, showing its role in protecting against DNA damage and its potential as a therapeutic target.

bioRxiv · Feb 5, 2021 · PreprintCancer Biology

GEMC1-MCIDAS transcriptional program regulates multiciliogenesis in the choroid plexus and acts as a barrier to tumorigenesis

Q. Li, Z. Han, N. Singh, B. Terre, R. M. Fame, U. Arif, T. D. Page, T. Zahran, A. Abdeltawab, Y. Huang, P. Cao, J. Wang, H. Lu, H. G. W. Lidov, K. Surendran, , H. Zhao

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

bioRxiv · Nov 22, 2020 · PreprintCancer Biology

Maintaining oxidized H3 in heterochromatin is required for the oncogenic capacity of triple-negative breast cancer cells

G. Serra-Bardenys, T. V. Tian, E. Blanco, J. Querol, L. Pascual-Reguant, B. Morancho, M. Escorihuela, S. Segura-Bayona, G. Verde, R. Aiese Cigliano, A. Millanes-Romero, C. Jerónimo, P. Nuciforo, S. Simonetti, C. Viaplana, , S. Peiró

This study identifies the role of H3K4ox in maintaining heterochromatin structure in TNBC cells and shows its necessity for oncogenic properties.

bioRxiv · Jan 30, 2020 · PreprintCancer Biology