BiophysicsbioRxiv
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
T. Kandola, S. Venkatesan, J. Zhang…·Randal Halfmann
This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.
DOI 10.7554/elife.86939.3