Pharmacology & ToxicologybioRxiv
Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
B. Metaferia, T. Cellmer, E. B. Dunkerlberger…·W. A. Eaton
This paper screens a drug repurposing library to identify compounds that inhibit sickling in sickle cell disease, finding 106 potential anti-sickling drugs with 21 predicted to be viable oral therapies.
DOI 10.1073/pnas.2210779119