Cell BiologybioRxiv
The fast and superprocessive KIF1A predominately resides in a vulnerable one-head-bound state during its chemomechanical cycle
T. M. Zaniewski, A. M. Gicking, J. Fricks, W. O. Hancock
This study elucidates the chemomechanical cycle of KIF1A, revealing that it predominantly resides in a one-head-bound state during its cycle, with fast rear head detachment and tethered head attachment as key rate-limiting steps.
DOI 10.1016/j.bpj.2020.11.1165