A. M. Gicking

The paper investigates how kinesin-1, -2, and -3 motors compete with dynein during bidirectional transport and finds that all three families can withstand hindering loads through distinct kinetic strategies.

The paper uses simulations to study kinesin and dynein motor dynamics in bidirectional transport, finding that matched stall forces and independent detachment rates best replicate experimental velocity distributions.

This study uses optical tweezers to show KIF1A generates higher force and sustains longer attachment under hindering loads compared to KIF5B, with rapid microtubule reengagement.

This study elucidates the chemomechanical cycle of KIF1A, revealing that it predominantly resides in a one-head-bound state during its cycle, with fast rear head detachment and tethered head attachment as key rate-limiting steps.

The paper uses iSCAT microscopy to analyze dynein-dynactin-BicD2 motility, finding that p150 reduces diffusive behavior and enhances processive movement.

This study shows that PAKRP2, an orphan kinesin in Arabidopsis, moves processively along microtubules using a noncanonical stepping mechanism with small steps and lateral movements.

This study identifies OsKCH2 as a processive minus-end-directed kinesin-14 in plants, compensating for the absence of cytoplasmic dynein.