Author

J. G. Moffat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

G. P. Vigers· 2 shared L. M. Pegram· 2 shared N. G. Ahn· 2 shared D. B. Iverson· 1 shared D. N. Jones· 1 shared D. Smith· 1 shared D. Vaisar· 1 shared H. Chen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

G. P. Vigers

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2 papers

Recent·Most cited

BiochemistrybioRxivSep 12, 2023

Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2

J. W. Anderson, D. Vaisar, D. N. Jones…·N. G. Ahn

This study identifies 14 ATP-competitive ERK2 inhibitors that select for the R-state conformation, revealing structural changes and allosteric communication mechanisms.

DOI 10.7554/elife.91507

experimental assayprotein folding & dynamics

𝕏 PostBluesky

BiochemistrybioRxivMay 16, 2019

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

L. M. Pegram, J. C. Liddle, Y. Xiao…·N. G. Ahn

This paper shows how different ERK2 inhibitors shift conformational states by exploiting activation loop dynamics, affecting dephosphorylation rates.

DOI 10.1073/pnas.1906824116

humanstructural biology

𝕏 PostBluesky