ImmunologybioRxiv
Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
C. Maserumule, C. Passemar, O. Oh…·R. A. Floto
The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.
DOI 10.1016/j.celrep.2025.115657