The hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche
E. Gonzalez-Sanchez, J. Vaquero, D. Caballero-Diaz, J. Grzelak, N. P. Fuste, E. Bertran, J. Amengual, J. Garcia-Saez, B. Martin-Mur, M. Gut, A. Esteve-Codina, A. Alay, C. Coulouarn, S. Calero, P. Valdecantos, , I. Fabregat
This study shows that inhibiting EGFR in hepatocytes reduces liver fibrosis by altering immune cell populations and molecular mechanisms involved in inflammation and fibrogenesis.
bioRxiv · Nov 3, 2023Pathology