Pharmacology & ToxicologybioRxiv
Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma
S. Vichaikul, M. Gurrea-Rubio, M. A. Amin…·P.-S. Tsou
This study shows that inhibiting BET proteins, particularly BRD4, reduces skin fibrosis in scleroderma models by affecting calcium signaling and gene expression.