Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
J. Hamm, F. Hinrichsen, L. Schroder, N. Mishra, K. Shima, A. Walker, N. Sommer, K. Klischies, D. Prasse, J. Zimmermann, S. Kaiser, D. Bordoni, A. Fazio, G. Laue, V. Tremaroli, , F. Sommer
This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.
bioRxiv · Dec 22, 2020Immunology