J. Zimmermann

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

Gut-associated functions are favored during microbiome assembly across C. elegans life

This study examines microbiome assembly dynamics in C. elegans, showing increased gut-associated functions and enrichment of specific bacterial genera over the host's lifetime.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

The role of glutathione in periplasmic redox homeostasis and oxidative protein folding in Escherichia coli

This study investigates the role of glutathione in periplasmic redox homeostasis and oxidative protein folding in E. coli using genetically encoded redox probes.

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across age

ALLCatchR, a machine learning classifier, accurately assigns B-precursor ALL samples to molecular subtypes and identifies developmental trajectories using RNA-Seq data.

Bacterial colonizers of Nematostella vectensis are initially selected by the host before interactions between bacteria determine further succession

This study shows that host selection drives initial bacterial colonization in Nematostella vectensis, while subsequent succession depends on bacterial metabolic interactions.

Patterns of convergent somatic hypermutations in the adaptive immune response of Mus musculus

The paper identifies convergent somatic hypermutations in murine antibodies, finding structural clusters that may indicate antigen-independent adaptive mutations.

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

This study shows that Ubc8 promotes mitochondrial protein import by enhancing TOM complex assembly during metabolic transitions in yeast.

Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters

This study evaluates an intranasal vaccine formulation containing a proteosome-adjuvanted SARS-CoV-2 Spike protein, showing immunogenicity and efficacy in mice and hamsters against multiple variants.

Hierarchical organization of rhesus macaque behavior

This study identifies hierarchical organization in rhesus macaque behavior through automated posture analysis using 3D motion tracking data.

A novel Pan-viral prophylaxis strategy using vaccine adjuvant CAF09b protects against influenza virus infection

This study shows that the adjuvant CAF09b can protect mice from influenza infection when administered before viral exposure but not after.

OpenMonkeyChallenge: Dataset and Benchmark Challenges for Pose Tracking of Non-human Primates

The paper introduces a benchmark challenge and dataset for non-human primate pose tracking, demonstrating its effectiveness through comparison with existing datasets.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

An 8 Dipole Transceive and 24 Loop Receive Array for Non-Human Primate Head Imaging at 10.5T

This paper describes the development of a high-resolution RF coil for non-human primate brain imaging at 10.5T, achieving submillimeter anatomical and functional imaging with improved SNR and parallel imaging.

CeMbio - The C. elegans microbiome resource

The paper introduces CeMbio, a simplified natural microbiota for C. elegans, enabling causal studies of host-microbiome interactions through a resource with culturable strains and associated tools.

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

The paper identifies discrete populations of isotype-switched memory B cells in murine spleen and bone marrow, with distinct locations and characteristics.

Morphology of obligate ectosymbionts reveals Paralaxus gen. nov., a new circumtropical genus of marine stilbonematine nematodes

The paper describes a new genus of marine nematodes, Paralaxus, using morphology and molecular data, and highlights issues with COI barcoding in the group.

The functional repertoire encoded within the native microbiome of the model nematode Caenorhabditis elegans

The paper analyzes the metabolic capabilities of the native microbiome of C. elegans and shows it can synthesize all essential nutrients for the nematode.

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.