A. Wolf

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Subjective assessment and taste strips testing of gustatory function, at home, and in the lab

The paper compares lab and home-based taste strips tests for gustatory function in healthy subjects, finding similar results between settings but no correlation between self-rated taste ability and test scores.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

This study shows that systemic TB4 gene therapy prevents podocyte injury and albuminuria in mice with Adriamycin-induced glomerular disease.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.