Rapid characterisation of hERG channel kinetics II: temperature dependence
C. L. Lei, M. Clerx, K. A. Beattie, D. Melgari, J. Hancox, D. J. Gavaghan, L. Polonchuk, K. Wang, G. R. Mirams
This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.
bioRxiv · Apr 16, 2019Biophysics