Author

L. Polonchuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:electrophysiology· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

K. Wang· 4 shared D. J. Gavaghan· 3 shared G. R. Mirams· 3 shared M. Clerx· 3 shared C. L. Lei· 2 shared A. Agrawal· 1 shared D. Melgari· 1 shared J. Cooper· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

K. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Models of the cardiac L-type calcium current: a quantitative review

A. Agrawal, K. Wang, L. Polonchuk, J. Cooper, M. Hendrix, D. J. Gavaghan, G. R. Mirams, M. Clerx

This paper reviews 73 mammalian models of the cardiac L-type calcium current, finds large variability in their predictions, and provides model code and data sources.

bioRxiv · Oct 4, 2021Cell Biology

Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors

S. A. van der Vegt, L. Polonchuk, K. Wang, S. L. Waters, R. E. Baker

This paper develops a mathematical model of autoimmune myocarditis and shows how immune checkpoint inhibitors increase its risk.

bioRxiv · Sep 3, 2021Immunology

Rapid characterisation of hERG channel kinetics II: temperature dependence

C. L. Lei, M. Clerx, K. A. Beattie, D. Melgari, J. Hancox, D. J. Gavaghan, L. Polonchuk, K. Wang, G. R. Mirams

This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.

bioRxiv · Apr 16, 2019Biophysics

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

C. L. Lei, M. Clerx, D. J. Gavaghan, L. Polonchuk, G. R. Mirams, K. Wang

This paper introduces a 15-second high-throughput protocol to rapidly characterize hERG channel kinetics using automated patch clamp systems and validates it with a hierarchical Bayesian model.

bioRxiv · Apr 16, 2019Biophysics