Four ways to fit an ion channel model
M. Clerx, K. A. Beattie, D. J. Gavaghan, G. R. Mirams
The paper compares four methods for fitting ion channel models to single-cell measurements, finding that Methods 3 and 4 provide the best predictions.
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3 papers
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M. Clerx, K. A. Beattie, D. J. Gavaghan, G. R. Mirams
The paper compares four methods for fitting ion channel models to single-cell measurements, finding that Methods 3 and 4 provide the best predictions.
C. L. Lei, M. Clerx, K. A. Beattie…·G. R. Mirams
This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.
K. A. Beattie, A. P. Hill, R. Bardenet…·G. R. Mirams
This paper introduces a method using sinusoidal voltage protocols to rapidly characterize ion channel kinetics, demonstrating improved predictive models of ion currents in hERG channels.