The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
A. Pius, Z. Clemens, S. Sivakumar, A. Sahu, S. Shinde, H. Mamiya, N. Luketich, J. Cui, J. Hoeck, S. Kreuz, M. Franti, A. Barchowsky, F. Ambrosio
This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.
bioRxiv · Jul 22, 2020Physiology