PhysiologybioRxiv
The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
A. Pius, Z. Clemens, S. Sivakumar…·F. Ambrosio
This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.
DOI 10.7554/elife.61138