S. Sivakumar

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation

This study analyzes 3,600 SCLC cases to identify new genetic subtypes and insights into histological transformation, revealing associations between genetic alterations and survival outcomes.

The fidelity of genetic information transfer with aging skeletal muscle segregates according to biological processes

The paper quantifies age-related decline in transcription factor-target gene communication efficiency using single-cell RNA-seq data from skeletal muscle.

Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

This study develops edible IgY antibodies from chicken eggs that neutralize Omicron RBD binding to human ACE2 and formulates them into beverages for oral use.

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

PHOSPHATASE-REGULATED RECRUITMENT OF THE SPINDLE AND KINETOCHORE ASSOCIATED (SKA) COMPLEX TO KINETOCHORES

This study shows phosphatases PP1 and PP2A promote Ska complex recruitment to kinetochores, stabilizing microtubule attachment and opposing spindle checkpoint signaling.