Author

J. Holoshitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

B. Miglioranza Scavuzzi· 2 shared F. W. Miller· 2 shared V. van Drongelen· 2 shared A. H. Sawalha· 1 shared A. Sawalha· 1 shared B. Kaur· 1 shared E. A. Farkash· 1 shared F. Benavides· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

B. Miglioranza Scavuzzi

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2 papers

Recent·Most cited

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

B. Miglioranza Scavuzzi, V. van Drongelen, B. Kaur, J. Callahan Fox, J. Liu, R. A. Mesquita-Ferrari, J. M. Kahlenberg, E. A. Farkash, F. Benavides, F. W. Miller, A. Sawalha, J. Holoshitz

This study identifies a DRB1*03:01-encoded epitope that drives a lupus-like transcriptome and cellular aberrations in macrophages, revealing a noncanonical mechanism of HLA-disease association in SLE.

bioRxiv · May 31, 2022 · PreprintImmunology

Antigen Presentation-Independent Reciprocal Immune Modulation by HLA-DRB1 Allelic Epitopes that Associate with Autoimmune Disease Risk or Protection

V. van Drongelen, B. Miglioranza Scavuzzi, S. Veloso Nogueira, F. W. Miller, A. H. Sawalha, J. Holoshitz

The paper shows HLA-DRB1 alleles influence macrophage polarization independently of antigen presentation, affecting inflammatory responses linked to autoimmune disease risk or protection.

bioRxiv · Aug 25, 2020Immunology