R. Fang

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

ATR promotes mTORC1 activity via de novo cholesterol synthesis

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

Multiscale imaging of corneal endothelium damage and effects of Rho Kinase inhibitor application in mouse models of acute ocular hypertension

The paper uses multiscale imaging to study corneal endothelium damage in mouse models, finding that Rho Kinase inhibitors reduce fully-distorted tight junctions under acute ocular hypertension.

Quantify nanoscopic alterations associated with mitochondrial dysfunctions using three-dimensional single-molecule localization microscopy

This paper introduces a quantitative method to analyze mitochondrial morphology using 3D single-molecule localization microscopy, validated with simulated data and tested on altered mitochondria.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

This study identifies a tripartite interaction between rice stripe virus, insect salivary carbonic anhydrase, and a plant protein that facilitates virus infection by enhancing callose degradation.

Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography

The paper investigates how multiple forward scattering affects the measured scattering coefficient of whole blood in visible-light OCT, introducing a scaling factor to correct for this effect.

An Empirical Energy Landscape Reveals Mechanism of Proteasome in Polypeptide Translocation

The paper develops a free-energy landscape model of the proteasome ATPase complex to reveal how ATP hydrolysis drives substrate translocation through cooperative subunit movements.

Balanced-detection visible-light optical coherence tomography

This paper introduces balanced-detection visible-light OCT to improve sensitivity and reduce noise, enabling clearer retinal imaging in healthy volunteers.

Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

Androgen Receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

Admistration of Exogenous Melatonin Improves the Diurnal Rhythms of Gut Microbiota in High Fat Diet-Fed Mice

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

How conspicuous are peacock eyespots and other colorful feathers in the eyes of mammalian predators?

The paper assesses how colorful bird feathers appear to mammalian predators using visual modeling, finding they are often cryptic to these predators but visible to birds.

Effect of soybean molasses-adsorbents on in vitro ruminal fermentation characteristics, milk production performance in lactating dairy cows

This study evaluates the effects of soybean molasses-adsorbents on in vitro ruminal fermentation and milk production in dairy cows, finding that wheat bran and soybean hulls improve fermentation and milk quality.