ImmunologyLeukemiaPeer-reviewed
Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia
N. Noronha, C. Durette, B. E Silva…·G. Ehx
This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.
DOI 10.1038/s41375-024-02250-6