Author

J. I. Blanco Capurro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Lia· 2 shared A. Santino· 2 shared A. V. Chandran· 2 shared C. P. Modenutti· 2 shared J. C. Hill· 2 shared M. Hensen· 2 shared M. Marti· 2 shared N. Zitzmann· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Lia

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2 papers

Recent·Most cited

BiochemistrybioRxivJun 21, 2022

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

K. P. Guay, R. Ibba, J. L. Kiappes…·P. Roversi

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

DOI 10.1016/j.isci.2023.107919

humanexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivDec 25, 2019

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP glucose:glycoprotein glucosyl-transferase.

C. P. Modenutti, J. I. Blanco Capurro, R. Ibba…·P. Roversi

This study uses molecular dynamics simulations and structural analysis to characterize inter-domain motions in UGGT, revealing conformational flexibility and a proposed Parodi limit for substrate recognition.

DOI 10.1016/j.str.2020.11.017

structural biologymechanistic / dynamical model

𝕏 PostBluesky