Author

N. Zitzmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

M. Hensen· 4 shared S. Vasiljevic· 4 shared A. Lia· 3 shared A. Santino· 3 shared A. V. Chandran· 3 shared C. P. Modenutti· 3 shared D. S. Alonzi· 3 shared J. C. Hill· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

M. Hensen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies

R. Asor, A. Olerinyova, S. A. Burnap, M. S. Kushwah, F. Soltermann, L. P. Rudden, M. Hensen, S. Vasiljevic, J. Brun, M. Hill, L. Chang, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, D. Zhou, , P. Kukura

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

bioRxiv · Sep 14, 2023 · PreprintBiophysics

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

G. Tax, K. P. Guay, T. Solde, C. J. Hitchman, J. C. Hill, S. Vasilievic, A. Lia, C. P. Modenutti, K. R. Straatman, M. Molinari, A. Santino, D. N. Hebert, N. Zitzmann, P. Roversi, M. Trerotola

This study shows that knocking out UGGT1 or UGGT1/2 genes rescues secretion of a misfolded Trop-2 glycoprotein mutant in mammalian cells.

bioRxiv · May 30, 2023 · PreprintCell Biology

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

K. P. Guay, R. Ibba, J. L. Kiappes, M. De Benedictis, I. Zeni, J. D. Le Cornu, M. Hensen, A. V. Chandran, A. L. Kantsadi, A. T. Caputo, J. I. Blanco Capurro, Y. Bayo, J. C. Hill, K. Hudson, A. Lia, , P. Roversi

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

bioRxiv · Jun 21, 2022Biochemistry

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

T. Bharucha, B. Gangadharan, A. Kumar, A. C. Myall, N. Ayhan, B. Pastorino, A. Chanthongthip, M. Vongsouvath, M. Mayxay, O. Sengvilaipaseuth, S. Rattanavong, D. P. O'Brien, I. Vendrell, R. Fischer, B. Kessler, , SEAe collaborators

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

bioRxiv · Jun 19, 2022Microbiology

Analysis of SARS-CoV-2 spike glycosylation reveals shedding of a vaccine candidate

J. Brun, S. Vasiljevic, B. Gangadharan, M. Hensen, A. V. Chandran, M. L. Hill, J. L. Kiappes, R. A. Dwek, D. S. Alonzi, W. B. Struwe, N. Zitzmann

The paper compares glycosylation patterns between SARS-CoV-2 viral spikes and a vaccine candidate, showing differences in secretion pathways and potential implications for immune response and vaccine design.

bioRxiv · Nov 16, 2020 · PreprintBiochemistry

Allosteric inhibition of the SARS-CoV-2 main protease - insights from mass spectrometry-based assays

T. J. El-Baba, C. A. Lutomski, A. L. Kantsadi, T. R. Malla, T. John, V. Mikhailov, J. R. Bolla, C. J. Schofield, N. Zitzmann, I. Vakonakis, C. V. Robinson

The paper uses mass spectrometry to study SARS-CoV-2 main protease dimerization and allosteric inhibition by small molecules.

bioRxiv · Jul 29, 2020Biophysics

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

L. F. Sobala, P. Z. Fernandes, Z. Hakki, A. J. Thompson, J. D. Howe, M. Hill, N. Zitzmann, S. Davies, Z. Stamataki, T. D. Butters, D. S. Alonzi, S. J. Williams, G. J. Davies

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

bioRxiv · Jun 30, 2020Biochemistry

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP glucose:glycoprotein glucosyl-transferase.

C. P. Modenutti, J. I. Blanco Capurro, R. Ibba, S. Vasiljevic, M. Hensen, D. S. Alonzi, A. V. Chandran, J. C. Hill, J. Rushton, A. Kumar, S. Rubichi, A. Lia, G. Tax, L. Marti, A. Santino, , P. Roversi

This study uses molecular dynamics simulations and structural analysis to characterize inter-domain motions in UGGT, revealing conformational flexibility and a proposed Parodi limit for substrate recognition.

bioRxiv · Dec 25, 2019Biochemistry