BiochemistrybioRxiv
Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
C. C. Ward, J. I. Kleinman, S. M. Brittain…·D. K. Nomura
This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.
DOI 10.1021/acschembio.8b01083