Cancer BiologybioRxiv
The epithelial-mesenchymal transcription factor SNAI1 represses transcription of the tumor suppressor miRNA let-7 in cancer
H. Wang, E. Chirshev, N. Hojo…·J. Unternaehrer
This study shows SNAI1 represses let-7 miRNA, promoting stemness in cancer cells, and demonstrates nanoparticle-mediated SNAI1 knockdown reduces tumor burden.