J. J. Bull

The paper models how different protocols for exposing phages to novel bacterial strains affect the evolution of generalist versus specialist phages.

The paper generates and analyzes randomized barcodes in a DNA virus genome, identifies sequencing errors, and develops a method to correct them for accurate interpretation.

This study examines how gene drive resistance evolves and shows that multiple drives or ecological effects can reduce resistance risk, but inbreeding can still halt drive spread.

This paper develops models to identify conditions under which gene drives can evade resistance, showing that linkage between resistance and drive loci is critical to resistance evolution.

The paper models how human travel affects the persistence of vector-borne diseases in spatially structured populations with imperfect genetic interventions.

The paper uses mathematical models to show that directed attenuation of viral immune evasion pathways can reduce viral growth without compromising immunity, potentially enhancing vaccine effectiveness.

This study evaluates whether in vivo phage evolution can improve phage therapy outcomes and finds that informed phage selection is more effective than relying on within-host evolution.

The paper shows spatial structure in vector populations can hinder disease eradication by gene drive cargo by facilitating disease agent resistance evolution.

The paper shows that sib mating can evolve to counteract gene drives, maintaining mean fitness above zero and potentially preventing extinction.

This paper models within-host evolution of recombinant vector vaccines and finds that vaccine efficacy can be reduced by transgene loss, but this can be mitigated by increasing inoculum size or purity.