Author

J. J. Chiesa

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. R. Damato· 1 shared D. A. Golombek· 1 shared E. D. Herzog· 1 shared G. J. Patti· 1 shared K. Cho· 1 shared L. L. Trebucq· 1 shared M. F. Gonzalez-Aponte· 1 shared S. P. Cardenas-Garcia· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. R. Damato

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintSep 13, 2023

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

M. F. Gonzalez-Aponte, A. R. Damato, L. L. Trebucq…·E. D. Herzog

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

DOI 10.1101/2023.09.13.557630

mousehuman

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