MicrobiologybioRxiv
An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice
L. Eyer, A. Nougairede, M. Uhlirova…·D. Ruzek
This paper identifies an E460D substitution in TBEV RdRp that confers resistance to Galidesivir and attenuates the virus in mice.
DOI 10.1128/jvi.00367-19