A. Pierce

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

Combined PI3K and MAPK inhibition synergizes to suppress PDAC

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model

MRI-guided focused ultrasound with microbubbles increases panobinostat delivery and efficacy in a diffuse midline glioma mouse model, reducing tumor volume and improving survival.

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

Super elongation complex as a targetable dependency in diffuse midline glioma

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.