J. Jacobs

Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain

The paper uses intracranial-EEG and video data to show that brain regions switch between spectral states in sync, reflecting naturalistic behaviors and forming functional networks.

What makes Candida auris pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugs

This study identifies genetic and metabolic adaptations in pan-drug resistant Candida auris strains that enable resistance without fitness costs.

Barley variety Quest exhibits broad-spectrum, moderate quantitative resistance against diverse Xanthomonas translucens pathovar translucens

The paper develops a greenhouse spray inoculation protocol to screen barley germplasm for resistance against Xanthomonas translucens pv. translucens, confirming moderate resistance in cultivar Quest across diverse strains.

Mixed Wolbachia infections resolve rapidly during in vitro evolution

This study shows that the wMel Wolbachia strain outcompetes the promiscuous wRi strain in vitro across different host cell types, suggesting a deterministic outcome that may explain low natural mixed infections.

Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat

This study identifies and functionally validates the WAPO1 gene's role in increasing spikelets per spike in wheat, showing its positive correlation with yield potential.

Leakiness at the human-animal interface in Southeast Asia and implications for the spread of antibiotic resistance

The paper identifies antibiotic resistance elements shared between humans and animals in Cambodia, highlighting the need to address human-animal interface leaks to combat antimicrobial resistance.

Pan-resistant Candida auris: New York Sub-cluster Susceptible to Antifungal Combinations

The paper shows that pan-resistant Candida auris strains from a New York outbreak are susceptible to antifungal combinations, despite having mutations in multiple drug targets.

Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma

This study shows that prior radiation therapy promotes tumor aggressiveness in glioblastoma by inducing metabolic changes that create a protumorigenic microenvironment.

A natural, conditional gene drive in plants

The paper describes a conditional gene drive in plants that operates in response to herbicide application, demonstrating non-Mendelian inheritance through gametic and embryonic selection.