J. D. Gross

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

This study identifies SIRT5 as a proviral factor that interacts with SARS-CoV-2 Nsp14, enhancing viral replication and suggesting it as a therapeutic target.

The paper determines the structure of the poxvirus decapping enzyme D9, revealing its mechanism for recognizing and catalyzing the removal of the 5' cap from mRNA.

The paper shows Pat1 enhances Lsm1-7 binding to RNA by increasing cooperativity and multimerization, broadening RNA specificity.

This study reveals how Pat1 coordinates the assembly and activation of a decapping mRNP to promote 5-3 mRNA degradation through multiple mechanisms.