Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of S. aureus Infections
J. Jo, T. Upadhyay, E. C. Woods, K. W. Park, N. J. Pedowitz, J. Jaworek-Korjakowska, S. Wang, T. A. Valdez, M. Fellner, M. Bogyo
The paper develops oxadiazolone-based probes targeting FphE to specifically detect S. aureus infections through covalent modification of the enzyme's active site.
bioRxiv · Dec 11, 2023 · PreprintMicrobiology