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J. K. Tiemann

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Biophysics· 1

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Approach:deep learning· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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A. Stein· 1 shared H. Zschach· 1 shared K. Lindorff-Larsen· 1 shared

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2022-2022 · peak 1/yr

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1 shared paperBiophysics

A. Stein

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1 paper

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BiophysicsbioRxivJul 12, 2022

Interpreting the molecular mechanisms of disease variants in human membrane proteins

J. K. Tiemann, H. Zschach, K. Lindorff-Larsen, A. Stein

This paper investigates missense variants in human membrane proteins, finding that loss of stability is a common mechanism for pathogenicity in over half of the studied variants.

DOI 10.1016/j.bpj.2022.12.031

humanprotein structure

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