Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells
V. Nguyen, J. Kravitz, C. Gao, M. L. Hochman, D. Meng, D. Chen, Y. Wang, A. G. Jegga, S. Nelson, W. Tan
This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.
bioRxiv · Jul 18, 2023 · PreprintCell Biology