S. Nelson

Detection of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in New York City

The paper detects H5N1 clade 2.3.4.4b influenza viruses in urban birds in New York City and highlights the urban animal-human interface as a potential zoonotic risk.

Dynamic fibroblast-immune interactions shape wound healing after brain injury

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

Distinct latitudinal patterns of shifting spring phenology across the Appalachian Trail Corridor

The paper analyzes spring phenology shifts across the Appalachian Trail Corridor using citizen science data, finding differential temperature sensitivity and phenological window expansion in northern regions.

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.

Butyrate enhances Clostridioides difficile sporulation in vitro

This study shows butyrate increases C. difficile sporulation and modifies its metabolism in vitro, suggesting a role in its persistence in the gut.

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

Demystifying image-based machine learning: A practical guide to automated analysis of field imagery using modern machine learning tools

This paper provides a practical guide to applying image-based machine learning for marine research, demonstrating data preparation, model training, and troubleshooting techniques with a case study.

A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese non-human primate model

This paper develops a long-acting GDF15 analog that reduces food intake and body weight in obese monkeys, with potential for clinical obesity treatment.

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

Synthetic Natural Product-Inspired Peptides

This study introduces SNaPP, a method combining bioinformatics and chemical synthesis to discover novel bioactive peptides inspired by natural products, identifying 14 antibacterial peptides including activity against multidrug-resistant bacteria.

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

The paper shows TRPV1 channels and PI3K reciprocally regulate each other in response to NGF, with TRPV1's N-terminal ARD enhancing PI3K activity.