Author

J. L. Andersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

P. Nissen· 3 shared C. Soendenbroe· 2 shared M. U. Fruergaard· 2 shared A. Ingersen· 1 shared A. Karlsen· 1 shared A. Kotsubei· 1 shared A. L. Mackey· 1 shared A. Shahsavar· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiochemistry

P. Nissen

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Author profile →

7 papers

Recent·Most cited

Rules, hypergraphs, and probabilities: the three-level analysis of chemical reaction systems and other stochastic stoichiometric population processes

E. Smith, H. B. Smith, J. L. Andersen

The paper develops a three-level framework for analyzing stochastic chemical reaction systems, showing how constraints at earlier levels influence dynamics at later levels and applying it to biological sugar-phosphate chemistry.

bioRxiv · Dec 11, 2023Biochemistry

The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy

D. G. Broadbent, C. M. McEwan, T.-M. Tsang, D. M. Poole, B. C. Naylor, J. C. Price, J. C. Schmidt, J. L. Andersen

This study identifies poly-ubiquitin as a signal recruiting ATG9A to initiate basal autophagy by mediating autophagy foci assembly.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

Marked irregular myofiber shape is a hallmark of human skeletal muscle aging and is reversed by heavy resistance training

C. Soendenbroe, A. Karlsen, R. B. Svensson, M. Kjaer, J. L. Andersen, A. L. Mackey

This study identifies myofiber shape as a marker of skeletal muscle aging in humans and mice, showing that resistance training reverses shape irregularities in type II myofibers.

bioRxiv · Jun 5, 2023Physiology

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

C. T. A. Lewis, L. Tabrizian, J. Nielsen, J. Laitila, T. N. Beck, P. Aagaard, R. Hokken, S. Laugesen, A. Ingersen, J. L. Andersen, C. Soendenbroe, J. W. Helge, F. Dela, S. Larsen, R. E. Sahl, , J. Ochala

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

bioRxiv · Sep 23, 2022 · PreprintPhysiology

Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases

M. U. Fruergaard, C. J. F. Nielsen, C. Rosada, L. Iversen, J. L. Andersen, P. Nissen

The paper characterizes the activation mechanism of the C-terminal kinase domain of RSKs and develops constitutively active variants for inhibitor testing.

bioRxiv · Feb 18, 2022Biochemistry

The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle

M. U. Fruergaard, I. Dach, J. L. Andersen, M. Ozol, A. Shahsavar, E. M. Quistgaard, H. Poulsen, N. U. Fedosova, P. Nissen

The paper presents a crystal structure of the Na+,K+-ATPase in the E2-BeFx form, revealing structural insights into its functional cycle and ion binding mechanisms.

bioRxiv · Nov 8, 2021 · PreprintBiochemistry

Structures of the heart specific SERCA2a Ca2+-ATPase

P. Nissen, J. De Raeymaecker, A. Kotsubei, N. D. Drachmann, R. Derua, S. Smaardijk, J. L. Andersen, I. Vandecaetsbeek, J. Chen, M. De Mayer, E. Waelkens, C. E. Olesen, P. Vangheluwe

The paper presents the first crystal structures of SERCA2a, revealing structural and regulatory differences from SERCA1a and providing insights into its function in cardiac muscle.

bioRxiv · Jun 12, 2018Biochemistry