Author

J. Ochala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5 Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

C. T. A. Lewis· 3 shared E. Zanoteli· 3 shared H. Iwamoto· 3 shared J. Laitila· 3 shared Y. Levy· 3 shared E. Battey· 2 shared G. L. Close· 2 shared J. A. Ross· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersPhysiology

C. T. A. Lewis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Remodelling of Skeletal Muscle Myosin Metabolic States in Hibernating Mammals

C. T. A. Lewis, E. G. Melhedegaard, M. M. Ognjanovic, M. S. Olsen, J. Laitila, R. A. E. Seaborne, M. N. Gronset, C. Zhang, H. Iwamoto, A. L. Hessel, M. N. Kuehn, C. Merino, N. Amigo, O. Frobert, S. Giroud, , J. Ochala

This study examines changes in skeletal muscle myosin metabolic states during hibernation in different mammals, finding reduced ATP consumption and potential mechanisms for energy conservation.

bioRxiv · Nov 14, 2023 · PreprintPhysiology

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

R. Moreno-Justicia, T. Van der Stede, B. Stocks, J. Laitila, R. A. Seaborne, A. Van de Loock, E. Lievens, D. Samodova, L. Marin-Arraiza, O. Dmytriyeva, R. Browaeys, K. Van Vossel, L. Moesgaard, N. Yigit, J. Anckaert, , A. S. Deshmukh

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

bioRxiv · Sep 7, 2023Physiology

Muscle fibre size and myonuclear positioning in trained and aged humans

E. Battey, Y. Levy, R. D. Pollock, J. N. Pugh, G. L. Close, M. Kalakoutis, N. R. Lazarus, S. R. Harridge, J. Ochala, M. J. Stroud

The paper examines how age and physical activity affect muscle fibre size, myonuclear numbers, and myonuclear domain volumes in humans, finding that exercise preserves fibre size and MND relationships while inactivity reduces fibre size and disrupts these relationships.

bioRxiv · Aug 25, 2023Physiology

Human light meromyosin mutations linked to skeletal myopathies disrupt the coiled coil structure and myosin head sequestration

G. Carrington, A. Hau, S. Kosta, H. Dugdale, F. Muntoni, A. D'Amico, P. Van den Bergh, N. Romero, E. Malfatti, J. J. Vilchez, A. Oldfors, S. Pajusalu, K. Ounap, M. Giralt-Pujol, E. Zanoteli, , J. Ochala

This study investigates how mutations in MYH7 and MYH2 genes affect myosin structure and function, finding that they disrupt coiled-coil structure and increase ATP consumption without affecting contractile function.

bioRxiv · May 15, 2023 · PreprintPhysiology

Predominant myosin super-relaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

J. Ochala, C. T. A. Lewis, T. Beck, H. Iwamoto, A. Hessel, K. Campbell, G. Pyle

This study finds that myosin in DCM-affected dogs has increased super-relaxed state and is rescued by EMD-57033.

bioRxiv · Mar 10, 2023Pathology

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

C. T. A. Lewis, L. Tabrizian, J. Nielsen, J. Laitila, T. N. Beck, P. Aagaard, R. Hokken, S. Laugesen, A. Ingersen, J. L. Andersen, C. Soendenbroe, J. W. Helge, F. Dela, S. Larsen, R. E. Sahl, , J. Ochala

This study shows that endurance training increases the super-relaxed state of myosin in skeletal muscle, reducing ATP turnover and diminishing the effect of the drug Mavacamten.

bioRxiv · Sep 23, 2022 · PreprintPhysiology

Myonuclear alterations associated with exercise are independent of age in humans

E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison-Hughes, N. Lazarus, S. D. R. Harridge, T. Iskratsch, J. Ochala, M. Stroud

This study shows that exercise-induced changes in myonuclear shape and stiffness occur independently of age in humans, potentially preserving muscle function across the lifespan.

bioRxiv · Sep 20, 2022Cell Biology

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

J. A. Ross, Y. Levy, M. Ripolone, J. S. Kolb, M. Turmaine, M. Holt, M. Moggio, C. Fiorillo, J. Lindqvist, N. Figeac, P. Zammit, H. Jungbluth, J. Vissing, N. Witting, H. Granzier, , J. Ochala

This study identifies nuclear defects in nemaline myopathy caused by impaired contractility and cytoskeletal organisation in muscle fibres.

bioRxiv · Jan 28, 2019Cell Biology