Author

P. Vangheluwe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Van den Haute· 5 shared J. Eggermont· 3 shared M. Azfar· 3 shared V. Baekelandt· 3 shared S. H. L. Verhelst· 2 shared S. Martin· 2 shared A. Bongers· 1 shared A. Karsa· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCell Biology

C. Van den Haute

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma

M. Azfar, W. Gao, C. Van den Haute, L. Xiao, M. Karsa, R. Pandher, E. Ronca, A. Bongers, A. Karsa, D. Spurling, X. Guo, C. Mayoh, M. R. Burns, S. H. L. Verhelst, M. D. Norris, , K. Somers

This study identifies ATP13A3 as a polyamine transporter mediating DFMO-induced polyamine uptake in neuroblastoma, highlighting it as a therapeutic target.

bioRxiv · Feb 20, 2024 · PreprintCancer Biology

ATP13A3 Variants Promote Pulmonary Arterial Hypertension by Disrupting Polyamine Transport

B. Liu, M. Azfar, E. Legchenko, J. A. West, S. Martin, C. Van den Haute, V. Baekelandt, J. Wharton, L. Howard, M. Wilkins, P. Vangheluwe, N. W. Morrell, P. D. Upton

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

bioRxiv · Aug 29, 2023 · PreprintCell Biology

The lipid flippase ATP10B enables cellular lipid uptake under stress conditions

R. Wouters, I. Beletchi, C. Van den Haute, V. Baekelandt, S. Martin, J. Eggermont, P. Vangheluwe

This study shows that ATP10B, a lipid flippase, enhances cellular phosphatidylcholine uptake under stress conditions like rotenone treatment.

bioRxiv · Jun 1, 2023Cell Biology

ATP13A4 upregulation drives the elevated polyamine transport system in the breast cancer cell line MCF7

S. van Veen, A. Kourti, E. Ausloos, J. Van Asselberghs, C. Van den Haute, V. Baekelandt, J. Eggermont, P. Vangheluwe

This study identifies ATP13A4 as a key polyamine transporter upregulated in breast cancer cells, contributing to increased polyamine uptake and sensitivity to polyamine toxicity.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system

M. C. Houdou, N. Jacobs, J. Coene, M. Azfar, R. Vanhoutte, C. Van den Haute, J. Eggermont, V. Daniels, S. H. L. Verhelst, P. Vangheluwe

The paper develops green fluorescent polyamine analogs to study ATP13A2 and ATP13A3 polyamine transport activity and identifies structure-activity relationships for isoform-specific transport.

bioRxiv · Dec 15, 2022Biochemistry

Structures of the heart specific SERCA2a Ca2+-ATPase

P. Nissen, J. De Raeymaecker, A. Kotsubei, N. D. Drachmann, R. Derua, S. Smaardijk, J. L. Andersen, I. Vandecaetsbeek, J. Chen, M. De Mayer, E. Waelkens, C. E. Olesen, P. Vangheluwe

The paper presents the first crystal structures of SERCA2a, revealing structural and regulatory differences from SERCA1a and providing insights into its function in cardiac muscle.

bioRxiv · Jun 12, 2018Biochemistry