Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice
H. Tao, J. Huang, P. G. Yancey, V. Yermalitsky, L. Ding, Y. Zhang, J. L. Blakemore, I. Zagol-Ikapitte, V. Amarnath, O. Boutaud, J. A. Oates, L. J. Roberts, S. S. Davies, M. F. Linton
This study shows that 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic mice by scavenging reactive dicarbonyls and improving HDL function.
bioRxiv · Aug 23, 2019 · PreprintPharmacology & Toxicology