Author

J. L. Rabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. S. Chavez· 3 shared E. M. Pietras· 2 shared G. Hernandez· 2 shared J. DeGregori· 2 shared T. S. Mills· 2 shared A. Goodspeed· 1 shared B. M. Idler· 1 shared B. M. Stevens· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

J. S. Chavez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PU.1 expression defines distinct functional activities in the phenotypic HSC compartment in a mouse model of inflammatory stress

J. S. Chavez, J. L. Rabe, G. Hernandez, T. S. Mills, K. E. Nino, P. Davizon-Castillo, E. Pietras

The paper shows that PU.1 expression levels in phenotypic HSCs define distinct functional activities under steady-state and inflammatory conditions.

bioRxiv · Oct 25, 2021 · PreprintCell Biology

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

J. S. Chavez, J. L. Rabe, D. Loeffler, K. Higa, G. Hernandez, T. S. Mills, N. Ahmed, R. L. Gessner, Z. Ke, B. M. Idler, H. M. Kim, J. R. Myers, B. M. Stevens, C. T. Jordan, H. Nakajima, , E. M. Pietras

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Journal of Experimental Medicine · Apr 15, 2021Peer-reviewedImmunology

Chronic Interleukin-1 exposure triggers selective expansion of Cebpa-deficient multipotent hematopoietic progenitors

K. C. Higa, A. Goodspeed, J. S. Chavez, V. Zaberezhnyy, J. L. Rabe, D. G. Tenen, E. M. Pietras, J. DeGregori

This study shows chronic IL-1β exposure selects for Cebpa-deficient HSPC by promoting myeloid differentiation and repressing stem cell programs, linking chronic inflammation to hematologic disorders.

bioRxiv · Mar 25, 2020Cancer Biology