Author

K. C. Higa

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

A. Goodspeed· 1 shared D. G. Tenen· 1 shared E. M. Pietras· 1 shared J. DeGregori· 1 shared J. L. Rabe· 1 shared J. S. Chavez· 1 shared V. Zaberezhnyy· 1 shared

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2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Goodspeed

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1 paper

Recent·Most cited

Cancer BiologybioRxivMar 25, 2020

Chronic Interleukin-1 exposure triggers selective expansion of Cebpa-deficient multipotent hematopoietic progenitors

K. C. Higa, A. Goodspeed, J. S. Chavez…·J. DeGregori

This study shows chronic IL-1β exposure selects for Cebpa-deficient HSPC by promoting myeloid differentiation and repressing stem cell programs, linking chronic inflammation to hematologic disorders.

DOI 10.1084/jem.20200560

mousebulk RNA-seq

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