ImmunologyJournal of Experimental MedicinePeer-reviewed
Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
J. S. Chavez, J. L. Rabe, D. Loeffler…·E. M. Pietras
This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.
DOI 10.1084/jem.20201169