J. L. Robertson

Mitigation of membrane morphology defects explain stability and orientational specificity of CLC dimers

This study shows that CLC-ec1 dimers stabilize by eliminating a membrane defect, using simulations and experiments to support this mechanism.

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

This study analyzes the thermodynamics of CLC transporter dimerization in lipid bilayers, finding a large negative heat capacity change linked to solvent ordering effects.

Dimerization mechanism of an inverted-topology ion channel in membranes

This study investigates the dimerization mechanism of the inverted-topology fluoride channel Fluc, showing that membrane forces drive assembly while Na+ binding activates the channel.

A single-molecule method for measuring fluorophore labeling yields for the study of membrane protein oligomerization in membranes

This paper introduces a method to estimate fluorophore labeling yields for membrane proteins using photobleaching analysis of a dimeric control, improving quantification of oligomerization without prior labeling measurement.

Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface

This study shows that non-polar side-chains at the dimerization interface of CLC-ec1 are important for dimer stability, but dimer stoichiometry depends on the solvent environment.

Dimerization of a membrane transporter is driven by differential energetics of lipid solvation of dissociated and associated states

Occupancy distributions of membrane proteins in heterogeneous liposome populations

The paper determines the occupancy distribution of membrane proteins in heterogeneous liposome populations, showing that liposome size distribution affects protein occupancy statistics.

A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers

The paper measures CLC-ec1 dimerization free energies in lipid bilayers using a model-free approach by analyzing single-molecule photobleaching data with corrected liposome size distributions.