R. Chadda

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

Fluorescent human RPA to track assembly dynamics on DNA

This paper describes fluorescently modified human RPA to study its dynamic interactions with ssDNA and other proteins.

Mitigation of membrane morphology defects explain stability and orientational specificity of CLC dimers

This study shows that CLC-ec1 dimers stabilize by eliminating a membrane defect, using simulations and experiments to support this mechanism.

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

This study analyzes the thermodynamics of CLC transporter dimerization in lipid bilayers, finding a large negative heat capacity change linked to solvent ordering effects.

Homodecameric Rad52 promotes single-position Rad51 nucleation in homologous recombination

This study reveals that homodecameric Rad52 facilitates single-position Rad51 nucleation in homologous recombination through specific structural and interaction features.

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

This study identifies a mitosis-specific regulation of RPA by Aurora B kinase, showing that phosphorylation of RPA70 at Ser-384 is essential for chromosome segregation fidelity and genomic stability.

Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins

This study shows Rtt105 binds to RPA, staples it, and blocks RIP interactions without ssDNA, while stabilizing RPA-ssDNA filaments with ssDNA.

Dimerization of a membrane transporter is driven by differential energetics of lipid solvation of dissociated and associated states

Occupancy distributions of membrane proteins in heterogeneous liposome populations

The paper determines the occupancy distribution of membrane proteins in heterogeneous liposome populations, showing that liposome size distribution affects protein occupancy statistics.

A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers

The paper measures CLC-ec1 dimerization free energies in lipid bilayers using a model-free approach by analyzing single-molecule photobleaching data with corrected liposome size distributions.