Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations
S. Li, A. Wong, H. Sun, V. Bhatia, G. Javier, S. Jana, R. B. Mongomery, J. L. Wright, H.-M. Lam, A. C. Hsieh, B. M. Faltas, M. C. Haffner, J. K. Lee
This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.
bioRxiv · Apr 12, 2023 · PreprintCancer Biology