S. Adams

Absolute quantification of rare gene targets in limited samples using crude lysate and ddPCR

This paper develops and validates a crude lysate ddPCR assay for accurate absolute quantification of rare genes like TRECs from limited clinical samples, eliminating DNA extraction and improving performance over standard ddPCR.

ENDO-LYSOSOME-TARGETED NANOPARTICLE DELIVERY OF ANTIVIRAL THERAPY FOR CORONAVIRUS INFECTIONS

This study develops lysosome-targeted nanoparticles loaded with mefloquine to inhibit coronavirus infection, showing effectiveness against SARS-CoV-2 and its variants in cell models.

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

This study shows that combining MPLA and IFNγ reprograms macrophages to kill cancer cells and reduce metastasis in breast and ovarian cancer models.

A model screening pipeline for bile acid converting anti-Clostridioides difficile bacteria reveals unique biotherapeutic potential of Peptacetobacter hiranonis

The paper develops a screening pipeline to identify bile acid converting bacteria with anti-C. difficile properties, isolating Peptacetobacter hiranonis with unique biotherapeutic potential.

Sexual morph specialisation in a trioecious nematode balances opposing selective forces.

This study shows that selfing and outcrossing sexual morphs in Auanema freiburgensis are specialised for distinct life cycle roles, balancing opposing selective forces and enabling stable coexistence.

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

The paper reports crystal and cryo-EM structures of zebrafish RET revealing conformational flexibility and strict geometric spacing in ligand-co-receptor recognition.

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets

This study develops an LED-based transcranial photoacoustic method to measure oxyhemoglobin saturation in neonatal piglets under hypoxia, achieving low error rates for potential clinical monitoring.

The Ancient DNA Insights into Aboriginal Australian Mortuary Practices

This paper uses ancient DNA analysis to study mortuary practices of Aboriginal Australians, finding that burial location may reflect geographic origin rather than social status.