A. Wong

Limit of detection of Salmonella ser. Enteritidis using culture-based versus culture-independent diagnostic approaches

This study compares the limit of detection of Salmonella ser. Enteritidis using culture-based and culture-independent methods, finding comparable LOD50 for qPCR and shotgun sequencing, but false positives in unspiked samples and lower LOD50 in feed than caecal contents.

Unpredictability of the fitness effects of antimicrobial resistance mutations across environments in Escherichia coli

This study shows that the fitness effects of antimicrobial resistance mutations vary widely across genetic backgrounds and environments in Escherichia coli, challenging assumptions about their predictability.

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin

This study shows early-life thermal stress increases TSP-1 in C. elegans, leading to longevity and resilience through tetraspanin web formation.

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.

Pathogenesis of Breakthrough Infections with SARS-CoV-2 Variants in Syrian Hamsters

This study investigates SARS-CoV-2 variant pathogenesis in Syrian hamsters, finding that prior infection reduces disease severity upon reinfection with different variants.

Sensitivity of diffusion-tensor and correlated diffusion imaging to white-matter microstructural abnormalities: application in COVID-19

This study compares diffusion MRI methods to detect white-matter changes in COVID-19 patients, finding correlated diffusion imaging is most sensitive to microstructural abnormalities.

Mortality without springing a leak: Locust gut epithelia do not become more permeable to fluorescent dextran and bacteria in the cold

This study investigates whether cold stress increases gut permeability in locusts by testing bacterial and fluorescent dextran leakage, finding no significant increase.

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

The paper identifies a microbial energy metabolism-driven niche in tertiary lymphoid organs that supports intestinal macrophage development via CSF2 and ILC3 activity.

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

Environment Classification for Robotic Leg Prostheses and Exoskeletons using Deep Convolutional Neural Networks

This paper develops an environment classification system for robotic leg prostheses and exoskeletons using deep convolutional neural networks, achieving accurate and efficient real-time predictions of walking environments.

Non-destructive Chemical Imaging of Bone Tissue for Intraoperative and Diagnostic Applications

This study uses multimodal imaging and machine learning to analyze bone tissue, achieving >90% accuracy in distinguishing cancer-related diagnostic categories.

Longitudinal changes in diet cause repeatable and largely reversible shifts in gut microbial communities of laboratory mice and are observed across segments of the entire intestinal tract

Computer Vision and Deep Learning for Environment-Adaptive Control of Robotic Lower-Limb Exoskeletons

The paper develops an environment recognition system for robotic exoskeletons using computer vision and deep learning, achieving 73% classification accuracy on a new dataset.

Moonlighting adenylyl cyclases in plants: an Arabidopsis thaliana 9-cis-epoxycarotenoid dioxygenase as point in case

The paper identifies novel adenylyl cyclases in Arabidopsis thaliana, including NCED3, which shows AC activity and may moonlight in ABA synthesis and signaling.

ExoNet Database: Wearable Camera Images of Human Locomotion Environments

ExoNet provides a large-scale, open-source database of wearable camera images for human locomotion environments to improve image classification algorithms for exoskeletons and prostheses.

Citrullination of proteins as a specific response mechanism in plants

This study identifies citrullination as a post-translational modification in Arabidopsis thaliana, showing its presence in the proteome and its response to cold stress.

Data-driven inference of crosstalk in the tumor microenvironment

The paper develops a data-driven method to deconvolute bulk tumor transcriptomes and predict cancer-stromal crosstalk in 20 solid tumor types, revealing new insights into signaling patterns.

Factors influencing riverine utilization patterns in two sympatric macaques

The paper examines factors influencing riverine utilization in two sympatric macaque species and compares them with proboscis monkeys, finding that food availability and predation pressure drive their riverine behavior.

Chemoinformatic-guided engineering of polyketide synthases

This study uses chemoinformatics to engineer polyketide synthases for producing saturated β-carbon compounds, finding a correlation between chemical similarity and product titers.

The Arabidopsis Diacylglycerol Kinase 4 is involved in nitric oxide-dependent pollen tube guidance and fertilization

This study identifies DGK4 as an NO-responsive protein involved in pollen tube guidance and fertilization in Arabidopsis by showing its role in NO-dependent growth and re-orientation responses.

Spatial Transcriptional Mapping of the Human Nephrogenic Program

The paper spatially maps the human nephrogenic program using single-cell RNA sequencing and generates functional gene-networks to identify developmental disease genes and predict new targets.

Millipede genomes reveal unique adaptation of genes and microRNAs during myriapod evolution

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

Imaging-Genomics Study Of Head-Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes And Genomic Mechanisms Via Integration Of TCGA And TCIA

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival

The paper identifies a 350-gene set conserved between HR+ and HR- BCa/PCa cells that promotes HR-independent survival and treatment resistance.