Author

J. Lacroix

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Biophysics· 1

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Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

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A. Alsamarah· 1 shared C. Xie· 1 shared J. Hao· 1 shared P. Chatterjee· 1 shared W. M. Botello-Smith· 1 shared Y. Luo· 1 shared

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2017-2017 · peak 1/yr

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1 shared paperBiophysics

A. Alsamarah

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1 paper

Recent·Most cited

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic Lock

W. M. Botello-Smith, A. Alsamarah, P. Chatterjee, C. Xie, J. Lacroix, J. Hao, Y. Luo

This paper identifies a conserved electrostatic lock in STKR1 kinases that regulates kinase activity through a salt-bridge, showing how phosphorylation, FKBP12 dissociation, and mutations disrupt this lock to cause leaky signaling.

bioRxiv · Jul 31, 2017Biophysics