J. Hao

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

The impact of Arctic environments on human cerebral blood flow

This study examines changes in cerebral blood flow in Arctic conditions and finds reduced velocity and increased pulsatility in specific arteries.

An uncanonical CDK6 activity inhibits cilia function by suppressing axoneme polyglutamylation

This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.

Discovering SARS-CoV-2 neoepitopes and the associated TCR-pMHC recognition mechanisms by combining single-cell sequencing, deep learning, and molecular dynamics simulation techniques

This study identifies SARS-CoV-2 epitopes and their TCR recognition mechanisms using single-cell sequencing, deep learning, and molecular dynamics simulations.

Telomerase reactivation induces progression of mouse BrafV600E-driven thyroid cancers without telomere lengthening

This study shows that reactivating telomerase in mouse thyroid cancers driven by BrafV600E leads to progression to poorly differentiated tumors without telomere lengthening.

Characterization and Applications of Evoked Responses During Epidural Electrical Stimulation

This paper characterizes evoked responses during epidural electrical stimulation and shows how the ECAP component can detect lead migration and muscle activation.

Dimensional Reduction for Single Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

This paper uses single-molecule imaging to study DNA and nucleosome condensation by polyamines, HP1α, and Ki-67, revealing kinetic differences in condensation and dissolution.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

Structure determination of protein-peptide complexes from NMR chemical shift data using MELD.

The paper develops a hybrid MELD-NMR approach to determine structures of flexible protein-polypeptide complexes using only NMR chemical shift data, achieving accurate results for ET domain-BET protein interactions.

SerpinB3 drives cancer stem cell survival in glioblastoma

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

A dual reporter system identifies an intermediate state and sequential regulators of 2-cell-like-to-pluripotent state transition

The paper identifies an intermediate state during 2C-like-to-pluripotent state transition using a dual reporter system and finds key regulators involved in this process.

Multiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid Cancers

This study investigates the role of ETS factors in regulating TERT expression in thyroid cancers with mutant promoters, finding that multiple ETS factors influence TERT independently of mutations.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

The Actin Bundling Protein Fascin Promotes Lung Cancer Growth and Metastasis by Enhancing Glycolysis and PFKFB3 Expression

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

This paper introduces a novel non-invasive mouse model of HIPEC to study its efficacy in epithelial ovarian cancer.

Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

Resolving the Interactions Between Class 3 Semaphorin Receptors in Live Cells

This study uses PIE-FCCS to analyze receptor interactions in live cells, finding that Plexin D1 is monomeric while others form dimers or heteromers, with ligand-induced complex formation only observed for Plexin D1 and neuropilin-1.

LPA/PKD-1 signaling promotes development of arteriolar niche that supports self-renewal of breast cancer stem cells and stemness

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins

This paper investigates the structural interactions of the BRD3 ET domain with host and viral proteins, revealing polymorphic structural interfaces and conformational plasticity.

Tumor-stromal IL1β/ NFκB / ESE3 Signal Axis Drives Pancreatic Cancer Fibrosis, Chemoresistance, Prognosis

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

Designed peptides as potential fusion inhibitors against SARA-CoV-2 coronavirus infection

The paper designs peptides based on SARS-CoV-2 spike protein HR1/HR2 domains to inhibit viral fusion and entry into host cells, showing they can form complexes with HR1 peptides.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

The effects of soil depth on the structure of microbial communities in agricultural soils in Iowa, USA

This study examines how microbial community structure changes with soil depth in Iowa agricultural soils, finding decreased diversity and distinct composition patterns linked to environmental factors.

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

Seneca Valley virus intercellular transmission mediated by exosomes

This study shows that exosomes from SVV-infected cells can carry and transmit SVV between susceptible and non-susceptible cells, and this transmission is resistant to neutralizing antibodies.

Development of a New Method for the Highly Effective Identification of Cold Resistance in Living Avocado Varieties

The paper develops a new method to identify cold resistance in avocado varieties by measuring leaf capacitance, finding a significant negative correlation between capacitance and cold resistance.

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic Lock

This paper identifies a conserved electrostatic lock in STKR1 kinases that regulates kinase activity through a salt-bridge, showing how phosphorylation, FKBP12 dissociation, and mutations disrupt this lock to cause leaky signaling.