P. Chatterjee

Involvement of ArlI, ArlJ, and CirA in Archaeal Type-IV Pilin-Mediated Motility Regulation

This study identifies ArlI, ArlJ, and CirA as regulators of pilin-mediated motility in Haloferax volcanii through genetic and expression analyses.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

GIPC3 couples to MYO6 and PDZ domain proteins and shapes the hair cell apical region

This study identifies GIPC3's role in coupling MYO6 and PDZ domain proteins to shape the hair cell cuticular plate and stereocilia arrangement.

Control of stereocilia length during development of hair bundles

This study investigates how stereocilia length is controlled during hair bundle development in mice, identifying key proteins and mechanisms involved in length regulation.

Single-Cell Epitope-Transcriptomics Reveal Lung Stromaland Immune Cell Response Kinetics to Nanoparticle delivered RIG-I and TLR4 Agonists

This study uses CITE-seq to analyze lung cell responses to nanoparticle-delivered RIG-I and TLR4 agonists, showing early changes in gene expression and cytokine synthesis.

Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths

This study shows that hawkmoths use visual feedback for slow head stabilization and antennal mechanosensory feedback for fast roll movements, with Johnstons organ mediating the latter.

Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

The paper studies the evolution of a supergene in white-throated sparrows, finding reduced recombination, low degeneration, and balancing selection maintaining genetic diversity.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

Nostoc talks back: Temporal patterns of differential gene expression during establishment of the Anthoceros-Nostoc symbiosis

This study uses RNA-Seq to analyze gene expression changes in Anthoceros punctatus during symbiosis with Nostoc punctiforme, revealing temporal patterns of nitrogen fixation and plant responses to nitrogen starvation.

Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)

This study evaluates the antiviral activity of ODBG-P-RVn, an orally available prodrug of remdesivir, against SARS-CoV-2 and other viruses in human airway cells, showing improved efficacy compared to GS-441524.

Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons

This paper designs peptide beacons using deep learning to detect SARS-CoV-2 RBD with sub-picomolar sensitivity, enabling rapid diagnostic applications.

DNA Supercoiling Drives a Transition between Collective Modes of Gene Synthesis

The paper introduces a model showing DNA supercoiling drives a transition between cooperative and antagonistic RNA polymerase dynamics during gene synthesis.

Single-Cell Transcriptomic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells

This study uses single-cell RNA-seq and computational models to identify transcriptomic attributes predicting immunomodulatory potency of mesenchymal stromal cells.

Single-Cell RNAseq of Out-of-Thaw Mesenchymal Stromal Cells Shows Striking Tissue-of-Origin Differences and Inter-donor Cell-Cycle Variations

This study compares single-cell transcriptomes of out-of-thaw mesenchymal stromal cells from bone marrow and cord tissue, revealing tissue-of-origin differences and inter-donor cell-cycle variations.

Targeted Intracellular Degradation of SARS-CoV-2 RBD via Computationally-Optimized Peptide Fusions

This study designs ACE2-derived peptides to target and degrade SARS-CoV-2 RBD via E3 ubiquitin ligases, showing effective RBD degradation in human cells.

Sirolimus plus nintedanib treats vascular pathology in HHT mouse models

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

Mechanotransduction-dependent control of stereocilia dimensions and row identity in inner hair cells

This study shows that mechanotransduction channels specify and maintain stereocilia row identity and control their diameter in inner hair cells.

The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli

This study shows PTPN2 deficiency in mice promotes expansion of a novel adherent-invasive E. coli that worsens colitis.

Robust Genome Editing of Single-Base PAM Targets with Engineered ScCas9 Variants

This study engineers ScCas9 variants to enable robust genome editing at single-base PAM targets with improved activity and fidelity.

Accelerated evolution of oligodendrocytes in human brain

The paper compares gene expression evolution in neurons and oligodendrocytes across humans, chimpanzees, and rhesus macaques, finding accelerated evolution in oligodendrocytes linked to schizophrenia.

A Cas9 with Complete PAM Recognition for Adenine Dinucleotides

This paper identifies a Cas9 variant with expanded PAM recognition for adenine dinucleotides, enabling broader gene editing capabilities in human cells.

Divergent PAM Specificity of a Highly-Similar SpCas9 Ortholog

This study characterizes the PAM specificity of ScCas9, a Cas9 ortholog from Streptococcus canis, showing divergent PAM affinity and developing a bioinformatics pipeline to explore microbial PAM diversity.

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic Lock

This paper identifies a conserved electrostatic lock in STKR1 kinases that regulates kinase activity through a salt-bridge, showing how phosphorylation, FKBP12 dissociation, and mutations disrupt this lock to cause leaky signaling.

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

This study uses transmammary delivery of anti-BMP9/10 antibodies to induce HHT-like vascular defects in mouse neonates, revealing consistent retinal pathology and increased angiopoietin-2 expression.